Are you looking for Lupus Symptoms in Women? Lupus is a clinical syndrome, the cause of which remains uncertain. It is a member of the family of autoimmune rheumatic diseases. Lupus is more common in women, and certainly more common amongst the black and Chinese population. It’s clinical diversity is at least apparently matched by its serological diversity. The prevalence of lupus among Afro-Caribbeans is approximately five times that of a Caucasian population, and about 2 ˝ times that of an Asian population.
Lupus Symptoms in Women
Lupus is far from confined to the skin. Indeed, we now recognize lupus in all its many systemic forms, much of the work being done in this century in various parts of the United States. At least 10% of the patients in my cohort who have been misdiagnoses as suffering from lymphomas or other malignant diseases. Virtually all lupus patients of course have musculoskeletal involvement, substantial number have dermatologic involvement, and a large number of patients also have gastrointestinal disease. Perhaps nowhere is the clinical diversity shown that in the cerebral system, where anything from migraine to madness may be a feature of lupus. About 30% of patients with lupus presenting to a rheumatologist will turn out to have significant renal disease. Perhaps 40% will have cardiopulmonary disease and virtually all patients with lupus have some hematological manifestation or another.
For the final clinical conundrum, I’d like to draw your attention to thrombocytopenia. I’d like to persuade you, at least to my mind, that there are at least three sorts of thrombocytopenia in patients with lupus. There are a group of patients who present with what is generally regarded as idiopathic disease, idiopathic thrombocytopenia, until other features of lupus turn up some years later. The platelet count can certainly get very low with these patients and clinical symptoms referable to thrombocytopenia are very common. In addition I recognize a group of patients with what I call chronic persistent thrombocytopenia within the context of lupus. The platelet count here often runs between 50 and 125, but the clinical symptoms referable to this platelet count are much rarer. There are a similar number of patients who have a dramatic fall in their platelet counts. This can occur over a matter of weeks or months and there are again frequent clinical features relevant to the platelet counts. How best to treat these patients? This is a review of a number of patients with lupus or the antiphospholipid syndrome, reviewed by _ and myself some years ago. In our cohort 16.5% of patients had thrombocytopenia as judged by a platelet count of less than 100; 7.5% of these patients had thrombocytopenia linked to antiphospholipid antibodies and 6% have very severe thrombocytopenia, counts less than 15 with symptoms.
If each of the eight organ systems, based largely on clinical questions - and I stress that, clinical questions - we define disease activity on this A-E basis. Where A represents action. The patient is severely ill, has sufficiently severe clinical features that they require major immunosuppressive therapy. B for beware, in the sense that we already knew the patient was active. C for contentment. There is low level activity, not requiring much in the way of therapy. D for discount, in the sense that the disease was once active but is no longer active. And E for no evidence of disease in the system now or previously. Here’s an example of the way that this works. Take, for example, the cardiovascular assessment. In a patient who presents with cardiac failure or symptomatic effusion and two of these other features listed here, from pleuropericardial pain due to friction rub, to deteriorating lung function. That patient will be categorized for their cardiovascular assessment as an A. In contrast, if only two of these criteria were present, they would be categorized as a B. If only one criteria or mild chest pain was present, they would get a C. A D if there was previous involvement but none current, and E for no previous involvement.
Now all of these patients were treated initially with large doses of corticosteroids and a significant number of them failed to respond. What should you do then? There is some conflicting data in the literature but we have found that splenectomy done relatively early to be a very helpful way of proceeding. So, of 17 patients that we identified during this time period, 12 had lupus, four had antiphospholipid syndrome, and one had three features of lupus and what we referred to as lupus-like. Nine of these patients were eventually given a splenectomy. Six of them responded completely, two of them gave a partial response, which unfortunately was not sustained, and one patient died of an unrelated carcinoma. The patient with the lupus-like disease also did extremely well. So for us, we tend to treat patients with thrombocytopenia, especially the acutely presenting ones, with corticosteroids. If that doesn’t work within a few months we would proceed to splenectomy. We may use some IV Ig on the way.
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Pseudogout crystals Pseudogout crystals are small enough and dull enough that they’re relatively difficult to see. Well, how do you see them? You take a pallet spin it down or take fluids spin it down to a pallet resuspend it, your chances of seeing pyrophosphate crystals go up about 70% or if you use a pallet. This is clinically an acute podagra. The inflammation is so intense that you actually peel off the skin like a blister. How come this is not cellulitis, sometimes it is difficult to sort out, as I say, the two can co-exist. The location is consistent with gout; in this particular case you can see tophaceous draining. This is chronic polyarticular tophaceous gout in a female patient that mimics rheumatoid arthritis. No history of acute podagra, this patient is 75 years of age, underlying osteoarthritis with crystal deposition disease. Different disease in men and women.
The effect of Monosodium Glutamate The effect of monosodium glutamate on the apoptosis
of rat thymocytes and Bcl-2 protein expression
Voja Pavlović, Snežana Cekić
Arch Med Sci 2006; 2, 1: 28-31
Introduction: Monosodium glutamate (MSG) is the sodium salt of glutamic acid
widely spread in modern nutrition. Numerous recent studies have shown the
existance of glutamic receptors on different non-neuronal cells, which among
others also include lymphocytes and thymocytes. However, it has not yet been
precisely established what modulatory effect is created by the activation of these
receptors on the immune system cells.
Holoprosencephaly prognosis and pictures What is Holoprosencephaly definition? Holoprosencephaly (HPE, once known as arhinencephaly) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemispheres. Normally, the forebrain is formed and the face begins to develop in the fifth and sixth weeks of human pregnancy. Hox genes, which guide placement of embryonic structures, fail to activate along the midline of the head, allowing structures that are normally paired on the left and right to merge. The condition also occurs in other species, as with Cy, the Cyclops kitten.
The condition can be mild or severe. According to the National Institute of Neurological Disorders and Stroke (NINDS), "in most cases of holoprosencephaly, the malformations are so severe that babies die before birth.
Transient ischemic attacks Symptoms and Treatment Transient ischemic attacks (TIAs) are neurogical deficits (such as loss of vision in one eye, inability to speak, paralysis, or weakness of one side of the body) of sudden onset that last for less than 24 hours. Although they are symptomatically similar to minor strokes, they do no discernible lasting damage to brain function.
The major importance of TIAs is their role as a predictor of stroke. When a person describes a “light stroke”, it is often a TIA that is meant. If left untreated, TIAs can indeed lead to major strokes, with permanent damage to all parts affected.
Sinusitis Symptoms and Treatment Sinusitis is an infection (usually bacterial) of one or more of the sinuses. It occurs more commonly in adults than in children. The sinuses are air-filled cavities located within the facial bone structure and connected to the nose. There are four major groups; frontal, ethmoidal, sphenoidal, and maxillary.
The sinuses are lined with mucous membrane and are normally kept clear when mucus drains through them into the nasal passages. If they are obstructed, normal drainage cannot occur, and infection of the sinuses can result.
Best Blood Pressure Monitor 2011 Review Are you looking for Best Blood Pressure Monitor 2011? Here is some review for Best Blood Pressure Monitor 2011. High blood pressure is a major problem today and the biggest difficulty with this serious and often life-threatening condition is that it rarely displays any symptoms at all. For this reason, it is vital that we all have our blood pressure checked from time to time and there is no easier way to do that nowadays than by using your own home blood pressure monitor.
Modern automatic monitors are simple to use and most have large digital readouts which are also very easy to read. Many also have memory facilities which allow you to keep a record or your blood pressure readings over time and sometimes to print these out or to load them into your computer where they can be plotted into a clear graphical picture.
Multiple Sclerosis Symptoms Multiple sclerosis is characterized by recurrent or chronically progressive neurologic dysfunction caused by lesions in the CNS. The CNS lesions are characterized by multiple areas of demyelination in the CNS. The brain, optic nerves, and spinal cord may be affected.
Alchohol Abuse Facts and Effect In primary care outpatients, the
prevalence of alcohol disorders is 16-28%, and the prevalence of drug disorders
is 7-9%. Alcoholism is characterized by continuous or periodic impaired control
over drinking, preoccupation with alcohol, use of alcohol despite adverse
consequences, and distortions in thinking, most notably denial. Substance abuse
is a pattern of misuse during which the patient maintains control. Addiction or
substance dependence, is a pattern of misuse during which the patient has lost
Clinical assessment of alcohol
use and abuse
The amount and frequency of
alcohol use and other drug use in the past month, week, and day should be
evaluated. Determine whether the patient ever consumes five or more drinks at a
time (binge drinking). Previous abuse of alcohol or other drugs should be
What is Marijuana and the Effects on Brain and Body Approximately 25 years ago, marijuana became a cultural phenomenon, the symbol of one generation's disregard for another. The marijuana found on the streets at that time, however, lacked the potency of current crops. Crossbreeding of more potent variates, improved cultivation, and the part of the plant being used all contribute to increased levels of the delta90-tetrahydrocannabinol (THC), the major psychoactive drug found in marijuana. Some marijuana currently grown in the United States rivals the previously stringer varieties of Mexico, Jamaica, and other areas. The THC percentage of Cannabis saliva (the Indian hemp plant which marijuana is derived) in plants grown in the United Sates can range from 2% to as high as 7%. The higher the percentage of THC , the more potent the drug. Marijuana is composed of the dried leaves and flowering tops of the cannabis plant. Hashish, which has stronger effects, is processed from called hash oil. Marijuana is seed motor extensively than hashish in the United States.
Leprosy Symptoms, Causes and Treatment More than 10 million people are victims of leprosy, an infectious disorder also known as Hansen’s disease. Although leprosy is more common in tropical regions, where up to 10 percent of some population groups may be affected, the disease also occurs in several northern countries, including the United States, where the disease is found in coastal states from California through Texas and Louisiana, and from Florida to New York. Ancient medical writings indicate that leprosy was known in China and India about 3,000 years ago but did not spread to the eastern Mediterranean until A.D. 500 or 600.
Acute idiopathic thrombocytopenic purpura in adults following viral infection A.J. Kooter, P.W.G. van der Linden, G. de Klerk 174
Idiopathic thrombocytopenic purpura (ITP) can follow a
viral infection. We describe severe thrombocytopenia in two
adult patients preceded by varicella zoster and Epstein-Barr
virus infection, respectively. The differences between acute
and chronic ITP are discussed, as well as therapeutic
What are Liver Disease Symptoms Liver disease (also called hepatic disease) is a broad term describing any single number of diseases affecting the liver.Hepatitis, inflammation of the liver, caused mainly by various viruses but also by some poisons (e.g. alcohol), autoimmunity (autoimmune hepatitis) or hereditary conditions. Diagnosis is done by checking levels of Alanine transaminase
Non-alcoholic fatty liver disease, a spectrum in disease, associated with obesity and characterized as an abundance of fat in the liver; may lead to a hepatitis, i.e. steatohepatitis and/or cirrhosis.