Are you looking for Lupus Symptoms in Women? Lupus is a clinical syndrome, the cause of which remains uncertain. It is a member of the family of autoimmune rheumatic diseases. Lupus is more common in women, and certainly more common amongst the black and Chinese population. It’s clinical diversity is at least apparently matched by its serological diversity. The prevalence of lupus among Afro-Caribbeans is approximately five times that of a Caucasian population, and about 2 ½ times that of an Asian population.
Lupus Symptoms in Women
Lupus is far from confined to the skin. Indeed, we now recognize lupus in all its many systemic forms, much of the work being done in this century in various parts of the United States. At least 10% of the patients in my cohort who have been misdiagnoses as suffering from lymphomas or other malignant diseases. Virtually all lupus patients of course have musculoskeletal involvement, substantial number have dermatologic involvement, and a large number of patients also have gastrointestinal disease. Perhaps nowhere is the clinical diversity shown that in the cerebral system, where anything from migraine to madness may be a feature of lupus. About 30% of patients with lupus presenting to a rheumatologist will turn out to have significant renal disease. Perhaps 40% will have cardiopulmonary disease and virtually all patients with lupus have some hematological manifestation or another.
For the final clinical conundrum, I’d like to draw your attention to thrombocytopenia. I’d like to persuade you, at least to my mind, that there are at least three sorts of thrombocytopenia in patients with lupus. There are a group of patients who present with what is generally regarded as idiopathic disease, idiopathic thrombocytopenia, until other features of lupus turn up some years later. The platelet count can certainly get very low with these patients and clinical symptoms referable to thrombocytopenia are very common. In addition I recognize a group of patients with what I call chronic persistent thrombocytopenia within the context of lupus. The platelet count here often runs between 50 and 125, but the clinical symptoms referable to this platelet count are much rarer. There are a similar number of patients who have a dramatic fall in their platelet counts. This can occur over a matter of weeks or months and there are again frequent clinical features relevant to the platelet counts. How best to treat these patients? This is a review of a number of patients with lupus or the antiphospholipid syndrome, reviewed by _ and myself some years ago. In our cohort 16.5% of patients had thrombocytopenia as judged by a platelet count of less than 100; 7.5% of these patients had thrombocytopenia linked to antiphospholipid antibodies and 6% have very severe thrombocytopenia, counts less than 15 with symptoms.
If each of the eight organ systems, based largely on clinical questions - and I stress that, clinical questions - we define disease activity on this A-E basis. Where A represents action. The patient is severely ill, has sufficiently severe clinical features that they require major immunosuppressive therapy. B for beware, in the sense that we already knew the patient was active. C for contentment. There is low level activity, not requiring much in the way of therapy. D for discount, in the sense that the disease was once active but is no longer active. And E for no evidence of disease in the system now or previously. Here’s an example of the way that this works. Take, for example, the cardiovascular assessment. In a patient who presents with cardiac failure or symptomatic effusion and two of these other features listed here, from pleuropericardial pain due to friction rub, to deteriorating lung function. That patient will be categorized for their cardiovascular assessment as an A. In contrast, if only two of these criteria were present, they would be categorized as a B. If only one criteria or mild chest pain was present, they would get a C. A D if there was previous involvement but none current, and E for no previous involvement.
Now all of these patients were treated initially with large doses of corticosteroids and a significant number of them failed to respond. What should you do then? There is some conflicting data in the literature but we have found that splenectomy done relatively early to be a very helpful way of proceeding. So, of 17 patients that we identified during this time period, 12 had lupus, four had antiphospholipid syndrome, and one had three features of lupus and what we referred to as lupus-like. Nine of these patients were eventually given a splenectomy. Six of them responded completely, two of them gave a partial response, which unfortunately was not sustained, and one patient died of an unrelated carcinoma. The patient with the lupus-like disease also did extremely well. So for us, we tend to treat patients with thrombocytopenia, especially the acutely presenting ones, with corticosteroids. If that doesn’t work within a few months we would proceed to splenectomy. We may use some IV Ig on the way.
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Lichen Sclerosus Lichen sclerosus is an atrophic, shrinking disease that usually occurs in postmenopausal women. The main symptom, if any, is pruritus. It can appear in children but remits after the menarche. The skin thins to a dry, shiny, fragile, finely wrinkled, parchment-like appearance and the external genitalia contract and lose their shape and definition. White patches fuse into a symmetric, "keyhole" pattern, often encompassing the perianus. Telangiectasia and mid-line skin "splits" are common. Histologically the epidermis is thin with flattened rete pegs. The dermis is edematous and hyalinized, with a loss of elastic fibers. There is a chronic inflammatory infiltrate in the lower dermis.
Macrocytic Anemia Causes and Treatment Anemias that are associated with macrocytosis (a mean corpuscular volume of >100 fL) include those from liver disease, alcoholism, hypothyroidism, certain drug exposures, megaloblastic anemia, myelodysplasias, preleukemia, or those with marked reticulocytosis due to the larger size of the young erythrocytes.
Prostate Cancer Symptoms in Men What is prostate cancer?
Prostate cancer is a malignant (cancerous) tumor (growth) that consists of cells from the prostate gland. Generally, the tumor usually grows slowly and remains confined to the gland for many years. During this time, the tumor produces little or no symptoms or outward signs (abnormalities on physical examination).
Gluten Free Diet Plan Weight Loss A gluten-free diet is a diet that excludes foods containing gluten. Gluten is a protein found in wheat (including kamut and spelt), barley, rye, malts and triticale. It is used as a food additive in the form of a flavoring, stabilizing or thickening agent, often as "dextrin". A gluten-free diet is the only medically accepted treatment for celiac disease, the related condition dermatitis herpetiformis, and wheat allergy.
Causes of muscular dystrophy Muscular dystrophy (abbreviated MD) refers to a group of hereditary and non-hereditary, muscle diseases that weakens the musculoskeletal system and hampers locomotion. Muscular dystrophies are characterized by progressive skeletal muscle weakness, defects in muscle proteins, and the death of muscle cells and tissue. What are causes of muscular dystrophy?
In the 1860s, descriptions of boys who grew progressively weaker, lost the ability to walk, and died at an early age became more prominent in medical journals. In the following decade, French neurologist Guillaume Duchenne gave a comprehensive account of 13 boys with the most common and severe form of the disease (which now carries his name — Duchenne muscular dystrophy).
Coronary Artery Disease Treatment Guidelines It can be difficult to determine whether chest pain is caused by angina. Whenever a person develops symptoms that could be angina, a complete medical evaluation is needed to determine whether coronary artery disease is present and, if so, how severe it is (see also chapter 7). The individual's medical history and descriptions of the pain, actions that cause the pain, and actions that make it better may raise a doctor's suspicion of coronary artery disease, but these factors are not sufficient for actual diagnosis. Likewise, physical examination and blood tests may show that the patient is at risk, but cannot actually diagnose the condition.
An electrocardiogram may or may not show changes of cardiac ischemia. An exercise electrocardiogram, a ''stress test'' done while a person is performing a specific amount of exercise, is more likely to demonstrate whether coronary disease is present. A particular change in the electrocardiogram during exercise can demonstrate that coronary artery disease is present. Even an exercise electrocardiogram is not 100 percent reliable in diagnosing coronary artery disease.
Malaria Symptoms and Treatment Malaria, one of the common diseases in the world, gets its name from the Italian word for “bad air” because of an ancient belief that a mysterious substance in the air was the cause of the ailment. It is now known that the disease is caused by any of at least four parasites carried by Anopheles mosquitoes. According to the World Health Organization (WHO), malaria causes more than 300 million acute illnesses and at least one million deaths annually. Ninety percent of deaths due to malaria occur in Africa, mostly among young children. The disease was relatively rare in United States until the 1960s, when hundreds of cases began to appear among military personnel who apparently contracted the disease in south east Asia but did not develop symptom until they returned to the United States. The disease later occurred in soldiers who had never left the United States. It was apparently transmitted by domestic Anopheles mosquitoes that had become infested with the malaria parasites.
Paleo Diet Plan for Weight Loss The Paleo Diet is a way of eating that is very similar to the way our ancestors allegedly ate during the Paleolithic period, which was about 10,000 years ago. According to the Paleo Diet creator Dr. Loren Cordain the foods suggested in the Paleo Diet are high in the nutrients our bodies need to stay fit, and low in those that contribute to weight gain and illnesses related to too much weight gain.
The creators of the Paleo diet and recipes contend that the human body is genetically made to eat the way our ancestors did prior to the industrialization of agriculture.
Detached retina causes and Treatment Normally, the retina is firmly attached to the choroid, and underlying layer of tissue that is rich in blood vessels. If blood or other fluid collects between the retina and the choroid, the retina may become partially or totally detached. Fluid from the vitreous cavity (the fluid-filled space behind the lens) may penetrate beneath the retina because of a small hole in the retina. Fluid leaking out of certain blood vessels in the eye may also penetrate beneath the retina to cause detachment.
Blood Pressure Definition Classification and Measurement Devices Blood pressure definition
Blood pressure (BP) is the pressure exerted by circulating blood upon the walls of blood vessels, and is one of the principal vital signs. During each heartbeat, BP varies between a maximum (systolic) and a minimum (diastolic) pressure. The mean BP, due to pumping by the heart and resistance to flow in blood vessels, decreases as the circulating blood moves away from the heart through arteries.
Ephedra diet pills side effects and review Are you looking for Ephedra diet pills side effect and review? Many over-the-counter diet pill manufacturers say their product will help you see miraculous weight loss -- like losing up to 30 pounds in 30 days -- without diet or exercise. Their claims sound too good to be true, and most of them are.
A few pills, especially the newer prescription varieties (such as Meridia and Xenical), have been shown in clinical studies to help dieters shed a few pounds. But the majority of the ads you see on the Internet and TV are for products that are unregulated, untested and unproven.
Dissociative amnesia is inability to recall important personal information, usually of a traumatic or stressful nature, that is too extensive to be explained by ordinary forgetfulness and is not due to the direct effects of substance use or a neurological or other general medical condition. Five types of disturbance in recall have been described. In the following examples, the individual is involved in a traumatic automobile accident in which a loved one is killed.
Lupus Symptoms in Women Are you looking for Lupus Symptoms in Women? Lupus is a clinical syndrome, the cause of which remains uncertain. It is a member of the family of autoimmune rheumatic diseases. Lupus is more common in women, and certainly more common amongst the black and Chinese population. It’s clinical diversity is at least apparently matched by its serological diversity. The prevalence of lupus among Afro-Caribbeans is approximately five times that of a Caucasian population, and about 2 ½ times that of an Asian population.